1. Which of the following clinical events would meet the American College of Cardiology's (ACC's) definition of a major bleeding event?

2. In a patient taking apixaban, which laboratory assay result would exclude any significant anticoagulant effect from apixaban?

3. RB is a 73-year-old male who presents with shortness of breath, hypotension (blood pressure = 80/50 mmHg), and jugular venous distension after a car accident. Evaluation reveals a pericardial tamponade. When reviewing his medications with his wife, she tells you that he is on rivaroxaban 20 mg for his atrial fibrillation, and took his dose about 5 hours ago. What reversal strategy would you recommend for RB to the team?

4. Which of the following statements about the use of PCCs for the reversal of factor Xa (FXa) inhibitors is true?

5. AJ is a 65-year-old woman who is on apixaban for anticoagulation for her atrial fibrillation. She has recently experienced and been treated for an intracranial hemorrhage (ICH). According to the ACC, how long should you wait before resuming anticoagulation?

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