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1. What regimen is considered preferred for front-line unresectable or metastatic cholangiocarcinoma?

A. Capecitabine alone B. Gemcitabine alone C. 5-Fluorouracil (5-FU) + oxaliplatin D. Gemcitabine + cisplatin E. Unsure

2. Which of the following best characterizes the use of second-line therapy in unresectable or metastatic cholangiocarcinoma?

A. In patients with an isocitrate dehydrogenase 1 (IDH1) mutation, targeted therapy with infigratinib should be considered B. In patients with a fibroblast growth factor receptor-2 (FGFR2) fusion or rearrangement, targeted therapy with pemigatinib should be considered C. In patients without molecular alterations, chemotherapy with 5-FU + irinotecan should be considered as it was shown to be superior to 5-FU + oxaliplatin D. In patients with a FGFR2 fusion or rearrangement, targeted therapy with ivosidenib should be considered E. Unsure

3. What are potential adherence barriers to pemigatinib therapy?

A. Drug obtainment and cost B. Challenging self-administration regimen C. Adverse-effect profile D. All the above E. Unsure

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